The NFL rolls into Week 4 with Sunday morning football in Dublin, a strong afternoon slate, and a Monday Night doubleheader. Below is a complete game-by-game breakdown with lines and score predictions.
Seahawks (2–1) at Cardinals (2–1)
Thursday, Sept. 25 – 7:15 p.m. | Line: Cardinals -1.5
Seattle enters fresh off a total demolition of the Saints, with rookie wideout Tory Horton flashing as both a receiver and return man. Sam Darnold continues to impress, playing near-flawless football in a career resurgence.
Arizona faces another rugged defense, and the loss of James Conner to a season-ending ankle injury puts pressure on rookie Trey Benson to carry the ground game. Marvin Harrison Jr. has underwhelmed so far at just 3.3 catches per game, and the passing attack must improve.
Prediction: Seahawks 27, Cardinals 20
Seattle’s offense is in rhythm, and that gives them the edge in this key NFC West matchup.
Vikings (2–1) at Steelers (2–1)
Sunday, Sept. 28 – 8:30 a.m. | Line: Vikings -2.5
Minnesota is riding high after a dominant win behind Carson Wentz and a record-setting defensive performance from Isaiah Rodgers. His two forced fumbles, interception, and two touchdowns earned the first-ever perfect 99.9 PFF grade.
The Steelers defense also delivered last week, but the offense remains inconsistent. Jaylen Warren leads the team in both rushing and receiving yards, highlighting just how thin the attack has become.
Prediction: Steelers 20, Vikings 17
Both defenses force turnovers, but Wentz could struggle against a more disciplined Pittsburgh unit.
Commanders (2–1) at Falcons (1–2)
Sunday, Sept. 28 – 12 p.m. | Line: Commanders -2.5
Washington thrived without Jayden Daniels, as Marcus Mariota capably stepped in. Whether Daniels returns this week will be crucial.
Atlanta’s offense was anemic in last week’s blowout loss, leading to a staff shake-up. The defense must rebound against a solid Washington rushing attack.
Prediction: Falcons 24, Commanders 23
If Daniels sits, expect the Falcons to rally at home and edge out a close one.
Saints (0–3) at Bills (3–0)
Sunday, Sept. 28 – 12 p.m. | Line: Bills -16.5
Buffalo looks every bit like the AFC favorite, averaging over 30 points per game while controlling the line of scrimmage.
New Orleans was embarrassed 44-13 in Seattle and now faces a near-impossible task against an elite Bills squad.
Prediction: Bills 30, Saints 17
Buffalo keeps rolling while New Orleans creeps closer to next year’s #1 overall draft pick.
Browns (1–2) at Lions (2–1)
Sunday, Sept. 28 – 12 p.m. | Line: Lions -8.5
Cleveland’s defense continues to shine, allowing just 10 points to Green Bay. But Joe Flacco’s struggles limit their ceiling.
Detroit dominated Baltimore with 224 rushing yards on Monday night. This week they’ll meet their toughest test yet against the NFL’s best run defense.
Prediction: Lions 20, Browns 17
Detroit finds a way, but Cleveland keeps it close with defense.
Titans (0–3) at Texans (0–3)
Sunday, Sept. 28 – 12 p.m. | Line: Texans -7.5
Tennessee’s offense is a disaster. Rookie QB Cam Ward has been sacked 15 times already, and the ground game is nonexistent.
C.J. Stroud and the Texans have their own offensive woes, but the defense is keeping them in games.
Prediction: Texans 27, Titans 17
Houston gets its first win behind defense and just enough from Stroud.
Panthers (1–2) at Patriots (1–2)
Sunday, Sept. 28 – 12 p.m. | Line: Patriots -5.5
Carolina notched its first win with a 30–0 shutout of Atlanta, sparking hope for a turnaround.
New England’s five turnovers doomed them last week. With a young offense still finding its identity, miscues remain a concern.
Prediction: Panthers 27, Patriots 23
Carolina’s momentum carries through in a sloppy but close win.
Chargers (3–0) at Giants (0–3)
Sunday, Sept. 28 – 12 p.m. | Line: Chargers -6.5
The Chargers are rolling with three straight divisional wins, powered by a revitalized Keenan Allen.
New York’s schedule has been brutal, and with rookie Jaxon Dart making his first start, this could be a rough one for Giants fans.
Prediction: Chargers 33, Giants 10
LA’s defense feasts on the rookie and keeps their perfect record alive.
Eagles (3–0) at Buccaneers (3–0)
Sunday, Sept. 28 – 12 p.m. | Line: Eagles -3.5
Philadelphia staged a stunning comeback last week, rediscovering offensive rhythm.
Tampa Bay edged past the Jets, with rookie Emeka Egbuka continuing to shine, but third-down inefficiency lingers.
Prediction: Buccaneers 30, Eagles 27
A pivotal NFC matchup tilts to Tampa at home.
Jaguars (2–1) at 49ers (3–0)
Sunday, Sept. 28 – 3:05 p.m. | Line: 49ers -3.5
Jacksonville leaned on defense and Travis Etienne’s running to grind out a win.
San Francisco remains unbeaten even without Brock Purdy, thanks to emerging star Ricky Pearsall.
Prediction: Jaguars 20, 49ers 14
Etienne powers a road upset in a defensive battle.
Colts (3–0) at Rams (2–1)
Sunday, Sept. 28 – 3:05 p.m. | Line: Rams -3.5
Indianapolis has become a surprise contender behind its rushing attack and stingy defense.
The Rams need to bounce back after last week’s tough loss, and Puka Nacua remains a reliable weapon.
Prediction: Rams 31, Colts 24
LA slows Indy’s run game and protects home field.
Ravens (1–2) at Chiefs (1–2)
Sunday, Sept. 28 – 3:25 p.m. | Line: Ravens -2.5
Baltimore’s line issues continue to leave Lamar Jackson scrambling.
Kansas City picked up its first win and is getting a boost from emerging receiver Tyquan Thornton.
Prediction: Chiefs 30, Ravens 20
Mahomes and the defense steady the Chiefs while Baltimore’s struggles persist.
Bears (1–2) at Raiders (1–2)
Sunday, Sept. 28 – 3:25 p.m. | Line: Raiders -1.5
Chicago’s offense clicked in last week’s win, with Caleb Williams beginning to find his rhythm.
The Raiders have been sliding since their Week 1 victory and need more from rookie Ashton Jeanty.
Prediction: Bears 33, Raiders 27
Williams keeps building momentum as the Bears win a shootout.
Packers (2–1) at Cowboys (1–2)
Sunday, Sept. 28 – 7:20 p.m. | Line: Packers -6.5
Green Bay is looking to shake off a frustrating loss to Cleveland’s defense.
Dallas, already searching for answers, now faces a month without CeeDee Lamb. Their offense is poised to struggle and the defense has been a liability all season.
Prediction: Packers 28, Cowboys 27
Green Bay capitalizes on Dallas’ injuries to edge out the win in a thriller.
Jets (0–3) at Dolphins (0–3)
Monday, Sept. 29 – 6:15 p.m. | Line: Dolphins -2.5
Both teams are desperate for their first win. New York’s offense has been sputtering, while Miami’s season already has McDaniel on the hot seat.
Prediction: Jets 28, Dolphins 17
The Jets lean on the run game and control the clock for the upset.
Bengals (2–1) at Broncos (1–2)
Monday, Sept. 29 – 7:15 p.m. | Line: Broncos -7.0
Cincinnati’s turnover woes are mounting, and the run game is nonexistent.
Denver, despite back-to-back losses, has a defense capable of dictating games. Bo Nix needs a bounce-back, but the matchup favors the Broncos.
Prediction: Broncos 33, Bengals 30
Denver’s defense does just enough to seal it at home.
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